Lab results in the loop: how weekly data improves protein design

Abstract

We fed weekly lab results back into our design model for eight rounds on four targets. The share of designs with a KD under 10 nM (BLI) went from 4% in round 1 to 27% in round 8. Most of the gain came from data on designs that did not bind.

Citation

Patel S, Okafor L, Nguyen T. Lab results in the loop: how weekly data improves protein design. Applied Protein Design. 2026;3(2):112-125. Sample citation.